Specialized Green Chemo-Enzymatic Synthesis Solutions

Member of the California Life Sciences and Biocom

We’re pleased to announce that a new service offering tailored specifically for the biotech and pharmaceutical industries is coming soon. Designed to support accelerated R&D timelines, enhance operational efficiency, and strengthen regulatory readiness, this solution will help organizations navigate the complex landscape of drug discovery, development, and commercialization. Our team is putting the finishing touches on the service, and we look forward to sharing more details in the near future.

Stay tuned — NEW innovative support for your scientific and clinical programs is on the way…

Summary – Galectins are glycan-binding proteins translating the sugar-encoded information of cellular glycoconjugates into physiological activities, including immunity, cell migration, and signaling. Galectins also interact with non-glycosylated partners in the extracellular milieu, among which the pre-B cell receptor (pre-BCR) during B cell development. Here, we perform NMR experiments on native membranes to monitor Gal-1 binding to physiological cell surface ligands. We show that pre-BCR interaction changes Gal-1 binding to glycosylated pre-B cell surface receptors. At the molecular and cellular levels, we identify α-2,3-sialylated motifs as key targeted epitopes. This targeting occurs through a selectivity switch increasing Gal-1 contacts with α-2,3-sialylated poly-N-acetyllactosamine upon pre-BCR interaction. Importantly, we observe that this switch is involved in the regulation of pre-BCR activation. Altogether, this study demonstrates that interactions to non-glycosylated proteins regulate the glycan-decoding functions of galectins at the cell surface. [Cell Reports 2024, 48(8), 114541.]

Advance your biomedical research industry with help from CASSIA LLC. Founded in 2004, we are a privately held biotechnology company and clinical research organization (CRO) specializing in green chemo-enzymatic synthesis solutions for preparing stable isotope-labeled (D, C-13, N-15, O-17/18) metabolites, proteins, nucleic acids, and their analogs. 

Leveraging our unique core technology platforms and expertise, we bring responsible, cost-effective, and creative solutions to a variety of basic, translational, and biomedical research applications, such as: 

• MS 
• NMR 
• Assay Development 
• Metabolic Research 

CASSIA LLC laboratories are located in an eight-building, 150,700 sq. ft. research and development (R&D) business park in the Mira Mesa region of San Diego, CA. We occupy 1580 sq. ft. and are capable of carrying out both basic and applied research in: 

• Molecular Biology 
• Biocatalysis 
• Organic Synthesis 
• Protein and Nucleic Acid Production 

Contact us today to learn more about our biotechnology company and the products and services we provide.